Cutaneous squamous cell carcinoma clinical guideline

Guideline highlights

• Tumor classification using the Brigham and Women's Hospital system is recommended for the most accurate prognostication in localized cSCC.

• Stratification of localized cSCC using the National Comprehensive Cancer Network (NCCN) is recommended to provide practical clinical guidance for treatment of cSCC.

• Biopsy techniques for cSCC are recommended, with the aim of identify techniques that provide optimal information for diagnosis and management of care.

• In general, surgical therapy remains the most effective treatment for cSCC.

• Nonsurgical therapies (radiation therapy, cryosurgery) may be selected for low-risk tumors or if surgery is contraindicated, with the understanding that the cure rate may be lower.

• As there are limited treatment options for metastatic disease, early and complete treatment is important.

• Patients diagnosed with cSCC should have annual checks for recurrence or other new primary skin cancer(s).

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