DW Insights & Inquiries
Alaskapox is a newly recognized infectious disease due to an Orthopoxvirus likely transmitted by small mammals. Most cases are mild, but a fatal case has been reported in a presumably immunosuppressed host.
Targeting the MAPK/ERK and PI3K/AKT/mTOR pathway has led to the use of topical sirolimus for neurofibromas and oral selumetinib for children with plexiform neurofibromas.
SAS is an underrecognized disorder usually observed in children and typically resolves after puberty. It may be accompanied by psychological distress. Topical minoxidil and oral biotin may help therapeutically.
Patients presenting with extensive capillary malformations (port wine stains) on the trunk and extremities should be routinely screened for early-onset hypertension.
Senile gluteal dermatosis is an underrecognized frictional dermatosis seen mostly in thin, elderly patients. But the term “senile” is getting old and should be retired.
Healthy neonates presenting with cold abscesses in skin folds and growing methicillin-sensitive staph on culture may have this disorder. With appropriate treatment, it will not have any untoward sequelae.
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The American Academy of Dermatology gratefully acknowledges support from Bristol Myers Squibb.