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DW Insights & Inquiries

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Advances in pruritus therapeutics: It’s Greek to us

Recent studies on the oral kappa-opioid receptor difelikefalin demonstrate benefit in treating pruritus in several dermatoses such as atopic dermatitis, notalgia paresthetica, and chronic kidney disease.

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CXCR4 antagonist therapy based on a WHIM syndrome

Advances in understanding the pathomechanisms of WHIM syndrome are the prelude to treating this syndrome — and other diseases — with CXCR4 antagonists.

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BAP1 tumor predisposition syndrome

Patients with polydactylous onychopapillomas mandate evaluation for the BAP1-tumor predisposition syndrome.

Infantile perianal pyramidal protrusion and Hippocrates

Dermatologists must recognize infantile perianal pyramidal protrusion (and its clinical variants) to avoid inappropriate diagnostic and therapeutic measures.

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Recognizing cutaneous Balamuthia mandrillaris infection

Dermatologists should be familiar with cutaneous infection by the ameba Balamuthia mandrillaris. Early recognition and treatment of cutaneous disease may decrease the risk of death from granulomatous amebic encephalitis.

Card image for DWII on acne necrotica
Acne necrotica: A real head-scratcher

This is a puzzling, under-recognized disorder that may be very distressing for afflicted patients. Further research into the pathogenesis of this lymphocytic folliculitis is warranted so that more specific therapies can be developed.


The mission of DW Insights & Inquiries

To improve the practice of dermatology, while being stimulating, practical, thought-provoking, and enlightening by offering critical perspectives on current dermatologic literature meant to be used in the clinic today and in the future.

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