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DW Insights & Inquiries

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The pregnant pause in cutaneous lymphoma

CTCL during pregnancy presents unique challenges. Many standard therapies are contraindicated; topical steroids, phototherapy, and interferon are considered safe options. A multidisciplinary approach is necessary for optimal management.

Card image for DWII on IL-36 and pyoderma gangrenosum
The expanding horizon of anti-IL-36 therapy

The IL-36/IL-36R axis is crucial in the pathogenesis and treatment of generalized pustular psoriasis. Researchers have demonstrated the pathway may be instrumental in several other inflammatory dermatoses, as shown in pyoderma gangrenosum.

Consider capillary malformation-arteriovenous malformation

The diagnosis of CM-AVM syndrome should be recognized by vascular lesions surrounded by pallor. The risk of associated central nervous system AVMs mandates diagnostic confirmation and appropriate imaging assessment.

Card image for DWII on Atopic dermatitis hide and seek: The impending role of OX40 inhibition
Atopic dermatitis: The impending role of OX40 inhibition

The OX40/OX40 ligand signaling pathway is involved in the pathogenesis of atopic dermatitis. Current trials using OX40/OX40 ligand inhibitors are underway, which are promising.

Image for DWII of periocular hypopigmentation of the elderly
Periocular hypopigmentation of the elderly

POHE is a diagnosis of exclusion after vitiligo and post-inflammatory or medication-induced hypopigmentation are ruled out. POHE is likely due to a combination of actinic damage and intrinsic aging in those with lighter complexions.

Image for DWII on Cronkhite-Canada syndrome
Advances in therapy for the Cronkhite-Canada syndrome

Early recognition and treatment of the Cronkhite-Canada syndrome may significantly improve the prognosis of this potentially lethal disease.


The mission of DW Insights & Inquiries

To improve the practice of dermatology, while being stimulating, practical, thought-provoking, and enlightening by offering critical perspectives on current dermatologic literature meant to be used in the clinic today and in the future.

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