DW Insights & Inquiries
Lipid vacuoles (Jordans’ anomaly) in white blood cells in patients with ichthyotic disorders (resembling nonbullous congenital erythroderma or the erythrokeratodermas) are indicative — but not pathognomonic — of the Chanarin-Dorfman syndrome.
Eccrine mucin-producing sweat gland carcinomas are low-grade malignancies that rarely metastasize. They are characterized by mucin and neuroendocrine markers. Immunostaining for insulinoma-associated protein 1 helps to secure the diagnosis.
Squamoid eccrine ductal carcinomas may be highly aggressive malignancies characteristically observed on the head and neck of older men. Biopsies must be deep enough to ensure that these lesions are not diagnosed as squamous cell carcinomas.
The Cystic Fibrosis Dermatitis Arthritis Syndrome should be suspected in young (mostly female) cystic fibrosis patients presenting with episodic arthritis and rash.
As the use of epidermal growth factor inhibitors expands, dermatologists should be familiar with all aspects of the PRIDE syndrome.
Sebaceous carcinoma may appear de novo or as part of the Muir-Torre syndrome. Germline testing for Muir-Torre syndrome is the gold standard for diagnosis.
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