Can a man treat psoriasis while trying to start a family?
Men can use most psoriasis treatments while trying to get a woman pregnant. There is one exception—methotrexate (meth-oh-trex-ate). Methotrexate can cause serious birth defects if a man takes it while trying to get a woman pregnant. To prevent this, dermatologists recommend that a man stop taking methotrexate for three months before trying to get a woman pregnant.
Use a condom while she’s pregnant
After the woman becomes pregnant, a man can start taking methotrexate again. If he does, he should use condoms while having sex during her pregnancy.
Men and methotrexate
Dermatologists recommend that a man stop taking methotrexate for 3 months before trying to get a woman pregnant.
How to stop taking methotrexate
Before stopping methotrexate, see your dermatologist (or the doctor who prescribed it). You may need to start another treatment to prevent the psoriasis from worsening.
Suddenly stopping methotrexate can cause psoriasis to flare. It can also cause you to develop a more serious type of psoriasis.
Related AAD resources
Callen JP. “Does paternal exposure to methotrexate affect birth outcomes?” (summary and comment). Journal Watch: NEJM. 2011 Jun 11. Last accessed October 27, 2015.
Menter A, Korman NJ, et al. “Guidelines of care for the management of psoriasis and psoriatic arthritis Section 4. Guidelines of care for the management and treatment of psoriasis with traditional systemic agents.” J Am Acad Dermatol2009;61:451-85.
All content solely developed by the American Academy of Dermatology
The American Academy of Dermatology gratefully acknowledges the support from Amgen.