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Session Information

FRM F119 - Understanding and Treating Paraneoplastic Diseases

Open admission to eligible categories, no tuition or ticket


Date: Monday, March 24

CME Credits: 2.00

Location: Room 709/711

Time: 1:00 PM - 3:00 PM

Director: Sergei A. Grando, MD, PhD, FAAD - Handout

Learning Objectives:
Following this course, the attendee should be able to:

  • Identify clinical variants of the paraneoplastic autoimmune multiorgan syndrome (PAMS)
  • Recognize the pathophysiology of PAMS
  • Manage patients with PAMS.

The objective is to characterize diverse clinical and immunopathological features of paraneoplastic autoimmune multiorgan syndrome (PAMS) known as paraneoplastic pemphigus (PNP). In fact, PNP represents only a single manifestation of a heterogeneous autoimmune syndrome, or PAMS, in which patients, in addition to small airway occlusion and deposition of autoantibodies in different organs, may display a spectrum of at least five different clinical and immunopathological mucocutaneous variants (i.e., pemphigus-like, pemphigoid-like, erythema multiforme-like, graft-vs-host disease-like, and lichen planus-like). The pathophysiological mechanisms of PAMS involve both humoral and cellular autoimmunity responses. Treatment is difficult and prognosis is doomed.