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Session Information

FRM F129 - Autoinflammatory Syndromes: Diseases Rare and Not So Rare

Open admission to eligible categories, no tuition or ticket


Date: Monday, March 04

CME Credits: 2.00

Location: Palm Ballroom 2

Time: 3:30 PM - 5:30 PM

Director: Kieron S. Leslie, MBBS


  • Jeffrey Phillip Callen, MD, FAAD - Handout
  • Michel F Gilliet, PhD
  • Karoline Krause, MD
  • Tiffany C. Scharschmidt, MD, FAAD - Handout

Learning Objectives:
Following this course, the attendee should be able to:

  • Describe the concept of autoinflammation
  • Diagnose, investigate, and manage patients with autoinflammatory syndromes
  • Use new therapeutic agents that target mediators of innate immunity that may be useful for other inflammatory skin diseases

Autoinflammation is a concept, first coined over ten years ago, to describe conditions that are characterized by episodes of seemingly unprovoked inflammation in the absence of T cell activation or high autoantibody titer. This term was applied to a group of rare monogenic periodic fever syndromes. Autoinflammation is increasingly recognized as fundamental to the pathogenesis of common skin diseases such as hidradenitis suppurativa, pyoderma gangrenosum, and psoriasis. In this session, the cutaneous manifestations and systemic complications are reviewed to enhance the learner's management of such conditions. The session is designed for medical dermatologists consulting on patients with complex medical or systemic diseases and who are interested in pathogenesis and future therapeutic targets.


Monday, March 04
3:30 PMIntroduction / Dr. Leslie
3:50 PMInnate Immune system & Inflammatory Skin Disease / Gilliet
4:10 PMThe microbiome and autoinflammation / Dr. Scharschmidt
4:30 PMpyoderma Gangrenosum / Dr. Callen
4:50 PMThe diagnosis and treatment of periodic fever syndromes / Dr. Krause
5:10 PMQuestions & Answers / All faculty