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Session Information

CRS C008 - Structure & Function of the Skin

Tuition fee and ticket required for admission


Date: Friday, March 01 - Saturday, March 02

CME Credits: 11.00

Location: Room A106/107

Time: 9:00 AM - 5:00 PM

Director: John J. DiGiovanna, MD, FAAD - Handout


  • Radhika Atit, PhD - Handout
  • Rachael Clark, MD, PhD, FAAD
  • Richard August Clark, MD, FAAD
  • George Cotsarelis, MD, FAAD - Handout
  • Thomas N. Darling, MD, PhD, FAAD - Handout
  • Emma Guttman, MD, PhD, FAAD
  • Thomas J. Hornyak, MD, PhD, FAAD - Handout
  • Jenny J. Kim, MD, PhD, FAAD - Handout
  • Heidi H. Kong, MD, MHS, FAAD - Handout
  • Andrew P. Kowalczyk, PhD - Handout
  • Kenneth Howard Kraemer, MD, FAAD - Handout
  • James G. Krueger, MD, PhD, FAAD
  • Lloyd S. Miller, MD, PhD, FAAD - Handout
  • Dennis H. Oh, MD, PhD, FAAD - Handout
  • David S. Rubenstein, MD, PhD, FAAD - Handout
  • John T. Seykora, MD, PhD - Handout
  • Hensin Tsao, MD, PhD, FAAD
  • Mark C. Udey, MD, PhD, FAAD - Handout
  • Jouni J. Uitto, MD, PhD, FAAD - Handout
  • Kim B. Yancey, MD, FAAD - Handout

Learning Objectives:
Following this course, the attendee should be able to:

  • Define basic structures in the epidermis and dermis, and list their basic functions.
  • Summarize the pathophysiology of representative dermatologic diseases.
  • Describe the rationale of selected therapeutic agents.

Lectures will discuss normal structure and function of cells and tissues within the skin, and how they are impaired in representative diseases. Keratinocytes, melanocytes, Langerhans cells, the epidermal basement membrane, fibroblasts, connective tissue, and adnexal structures (hair, pilosebaceous units and sweat glands) will be discussed. Their abnormal functions will be related to pathology, including inflammation, autoimmunity, blistering, cancer, photosensitivity, dyspigmentation, infection, and genodermatoses. Examples will be shown of how new understanding of skin biology is being translated into therapies and improved patient care. Bringing a print or electronic copy of the handouts may facilitate following the lectures.


Friday, March 01
9:00 AMIntroduction / Dr. DiGiovanna
9:05 AMSkin Embryology and Morphogenesis / Atit
9:30 AMKeratinocyte Biology and Pathology / Dr. DiGiovanna
10:00 AMBreak /
10:15 AMEpidermal Cell-Cell and Cell-Matrix Adhesion / Kowalczyk
11:00 AMPemphigus: Anti-Desmosomal Autoimmune Diseases / Dr. Rubenstein
11:30 AMAutoimmune and Inherited Diseases of Epidermal Basement Membrane / Dr. Yancey
12:00 PMLunch /
2:00 PMOncogenes and Tumor Suppressor Genes / Dr. Darling
2:30 PMCutaneous Photobiology / Dr. Oh
3:00 PMDNA Repair Abnormalities and Skin Cancer / Dr. Kraemer
3:30 PMBreak /
3:45 PMExtracellular Matrix in Acquired and Inherited Skin Diseases / Dr. Uitto
4:15 PMMelanocytes and Disorders of Pigmentation / Dr. Hornyak
4:45 PMQuestions & Answers /
Saturday, March 02
9:00 AMIntroduction / Dr. DiGiovanna
9:05 AMAdnexal Structures in Skin / Dr. Seykora
9:45 AMDiseases of Hair / Dr. Cotsarelis
10:15 AMBreak /
10:30 AMDisease of the Pilosebaceous Unit / Dr. Kim
11:00 AMPathogenesis of BCC, SCC, and Melanoma / Dr. Tsao
11:30 AMSkin as an Immune Organ / Dr. Udey
12:00 PMLunch /
2:00 PMInnate Immunity / Dr. Miller
2:30 PMThe Cutaneous Microbiome / Dr. Kong
2:50 PMWound Healing / Dr. Clark.
3:15 PMBreak /
3:25 PMCurrent Concepts in Psoriasis / Dr. Krueger
4:00 PMCurrent Concepts in Atopic Dermatitis / Dr. Guttman
4:25 PMRegulatory T cells: The good, the bad, and the ineffective / Dr. Clark
4:45 PMQuestions & Answers / All faculty