Psoriasis: Biologics

Biologic agents are now routinely used when one or more traditional systemic agents fail to produce an adequate response, are not tolerated because of adverse effects, or are unsuitable because of the presence of comorbidities. Recommendations for use, baseline screening, vaccination and monitoring guidelines, absolute and relative contraindications, and adverse events associated with biologic agents have been comprehensively summarized (AAD Psoriasis Guidelines, Section 1). The currently approved biologic agents for the treatment of either psoriasis or PsA include alefacept, infliximab, etanercept, adalimumab, golimumab, and ustekinumab, with alefacept and ustekinumab FDA approved for psoriasis only and golimumab FDA approved for PsA only. Another anti-IL-12/23 antibody, briakinumab, is in the late stages of phase III clinical trials, whereas phase II and phase III clinical trials are ongoing for numerous other agents including anti-IL-17 antibodies, IL-17 receptor blockers, p-selectin inhibitors, and JAK inhibitors.

Navigate section 6 of the psoriasis guideline: Case-based review

Citation note

Menter A, Korman NJ, Elmets CA,Feldman SR, Gelfand JM, Gordon KB, Guidelines of care for the management of psoriasis and psoriatic arthritis: section 6. Guidelines of care for the treatment of psoriasis and psoriatic arthritis: case-based presentations and evidence-based conclusions. J Am Acad Dermatol. 2011 Jul;65(1):137-74. 

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