Atopic dermatitis: Recommendations for the use of systemic antihistamines

  • There is insufficient evidence to recommend the general use of antihistamines as part of the treatment of atopic dermatitis. 
  • Short-term, intermittent use of sedating antihistamines may be beneficial in the setting of sleep loss secondary to itch, but should not be substituted for management of atopic dermatitis with topical therapies.

    Strength of Recommendation: C Level of Evidence: III
  • Non-sedating antihistamines are not recommended as a routine treatment for atopic dermatitis in the absence of urticaria or other atopic conditions such as rhinoconjunctivitis.

    Strength of Recommendation: A Level of Evidence: II

Navigate section 3 of the AD guideline: Phototherapy and systemic agents   

Citation note

When referencing this guideline in a publication, please use the following citation: Sidbury R, Davis DM, Cohen DE, Cordoro KM, Berger TG, Bergman JN, et al. Guidelines of care for the management of atopic dermatitis: section 3. Management and treatment with phototherapy and systemic agents. J Am Acad Dermatol. 2014 Aug;71(2):327-49. 


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