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Beyond Spaghetti and Meatballs: What’s New on the Malassezia Menu
Friday, August 02
1:00 PM - 2:30 PM
Nikki A. Levin, MD, PhD, FAAD - Handout
Following this course, the attendee should be able to:
- Diagnose skin conditions caused by Malassezia (Pityrosporum) yeasts.
- Discuss pathogenic strategies employed by Malassezia yeasts and host responses to them.
- Choose appropriate treatments for Malassezia-related skin conditions, including tinea versicolor and Pityrosporum folliculitis.
Malassezia (formerly Pityrosporum) are dimorphic lipophilic fungi well established as a cause of human skin infections, including tinea versicolor and Pityrosporum folliculitis. In this session, we will discuss the new classification of Malassezia species, their microbiology, distribution and pathogenic strategies. We will review exciting new evidence suggesting how Malassezia interact with and evade the human immune system, including the role of the yeast capsule and indole alkaloid compounds, host antimicrobial peptides, and Toll-like receptor 2. We will present an evidence-based approach to the diagnosis and treatment of tinea versicolor and Pityrosporum folliculitis, and highlight some experimental therapies in the developmental pipeline. We will also evaluate the evidence implicating Malassezia in other skin conditions such as seborrheic dermatitis, atopic dermatitis, and scalp psoriasis, as well as rarer conditions such as granulomatous dermatitis.