Return to program book search
Session Information
DSG D006
-
Advances in Pemphigus & Pemphigoid
Open admission, no tuition or ticket
Subject:
Date:
Saturday, March 02
CME Credits:
2.00
Location:
Room C219
Time:
3:30 PM - 5:30 PM
Director:
Luis A. Diaz, MD, FAAD - Handout
Learning Objectives:
Following this course, the attendee should be able to:
- Discuss the pathogenesis of pemphigus and pemphigoid
- Formulate the best treatment for these patients
Description:
Structural skin molecules are targeted by “pathogenic” autoantibodies which are known to induce intra-epidermal and subepidermal blisters in experimental animals. In pemphigus vulgaris and pemphigus foliaceus, desmosomal antigens, i.e., Dsg3 and Dsg1 respectively, are the targets. In bullous pemphigoid hemidesmosomal antigens, i.e., BP230 and BP180, are bound by these autoantibodies. These pathogenic autoantibodies may trigger blister formation by different mechanisms, e.g., signal transduction, apoptosis or inflammation. Therapies aimed at eliminating pathogenic autoantibodies from these patients will be discussed.